Check if activation is blocked on that server for the DB. The error indicates that
Get-MailboxDatabaseCopyStatus MBX-DB1\EMAIL2 |FL activationsuspended
or for the entire server
Get-MailboxServer EMAIL2 | FL DatabaseCopyAutoActivationPolicy
If you want to remove that block:
Get-MailboxDatabaseCopyStatus MBX-DB1\EMAIL2 | Resume-MailboxDatabaseCopy